Researchers at University Medical Center Utrecht have uncovered a previously underappreciated mechanism that helps immune ...

DNA-based methods dominate molecular cancer diagnostics but struggle to detect gene fusions and assess splice site consequences. RNA sequencing enables sensitive fusion detection and direct assessment ...

Researchers from Children's Hospital of Philadelphia (CHOP) developed a new RNA sequencing strategy that can reveal how genetic variants disrupt gene function and improve the diagnosis of rare ...

While bulk sequencing quickly became the preferred method, scRNA-seq has increased in popularity over the last decade. In 2015, just 6 % of RNA-seq papers used single-cell methodologies. By 2025, the ...

Morgan Hiebert (left) studies drug-resistant tuberculosis within the National Reference Centre for Mycobacteriology (Winnipeg, Manitoba) led by Hafid Soualhine, situated in the National Microbiology ...

Rapid precision run-on sequencing (rPRO-seq) may help doctors understand disease states and treatment response in real time. Researchers at Sylvester Comprehensive Cancer Center (FL, USA) have ...

Inside every cell, thousands of molecular signals collide, overlap, and compensate, obscuring the true drivers of gene expression. Scientists have now developed a way to silence that cellular noise, ...

Understand the stages of a standard RNA-seq bioinformatics workflow, including the role of QC, alignment, gene expression quantification, and specialized application analyses Identify key QC metrics ...

Transcriptome-wide profiling of bacterial RNA pseudouridylation maps modification landscapes and nominates candidate regulatory sites, offering a resource and foundation for future mechanistic studies ...