In recent years, the application β-Lactams has been extended over their antibacterial properties. They have been used as a carrier for selective oncolytic drugs and as a potential neuro-protective ...

Synthetic chemists can go around in circles trying to make the cyclic amides known as lactams. That’s because lactams with 4-, 5-, and 6-membered rings—known as β-, γ- and δ-lactams, respectively—are ...

Scientists have designed a novel strategy to synthesize ring-shaped cyclic molecules, highly sought-after by pharmaceutical and chemical industries, and known as gamma-lactams. This study describes ...

The strained cyclic amides known as β-lac­tams have shown up in the skeletons of many medicinally important molecules, including the antibiotic penicillin and the cardiac drug Zetia (ezetimibe).

Prolonged infusion of beta-lactam antibiotics for sepsis or septic shock tended to improve mortality compared with conventional intermittent infusion in the BLING III trial, and a meta-analysis ...

In patients with suspected sepsis, the use of β-lactam therapy prior to vancomycin was associated with lower risk of in-hospital mortality compared with vancomycin prior to β-lactam therapy. The ...

Led by Director CHANG Sukbok, scientists from the Center for Catalytic Hydrocarbon Functionalizations within the Institute for Basic Science (IBS) have made a significant advancement in the synthesis ...

Obesity may alter the pharmacokinetics of β-lactams. The goal of this study was to evaluate if and why serum concentrations are inadequate when standard β-lactam regimens are administered to obese, ...

The researchers compared the effectiveness of oral beta-lactams to fluoroquinolones in the treatment of Enterobacteriaceae bloodstream infections (EBSI) in adult patients. This article is written live ...

Enzymes can not only learn from synthetic chemistry but can also enable new chemistry that has never been realized before. So say researchers at the California Institute of Technology who have ...

Standard tuberculosis treatment for drug-sensitive disease requires the simultaneous use of four drugs: rifampin, an RNA transcription inhibitor; isoniazid, a mycolic acid biosynthesis inhibitor; ...

AuroFlow™ PR1ME™ BT Combo MRL Assay is a competitive assay in a test strip format. It has been specifically designed to enable the rapid detection of residues of β-lactams in raw commingled cow’s milk ...